Protein Coevolution and Isoexpression in Yeast Macromolecular Complexes

Ettwiller, Laurence; Veitia, Reiner A.

doi:https://doi.org/10.1155/2007/58721

International Journal of Genomics

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Research Article | Open Access

Volume 2007 | Article ID 058721 | https://doi.org/10.1155/2007/58721

Protein Coevolution and Isoexpression in Yeast Macromolecular Complexes

Laurence Ettwiller^1,2and Reiner A. Veitia^3,4,5,6,7

Academic Editor: Pierre Legrain

Received04 Sept 2006

Revised20 Nov 2006

Accepted23 Nov 2006

Published08 Jan 2007

Abstract

Previous studies in the yeast Saccharomyces cerevisiae have shown that genes encoding subunits of macromolecular complexes have similar evolutionary rates (K) and expression levels (E). Besides, it is known that the expression of a gene is a strong predictor of its rate of evolution (i.e., E and K are correlated). Here we show that intracomplex variation of subunit expression correlates with intracomplex variation of their evolutionary rates (using two different measures of dispersion). However, a similar trend was observed for randomized complexes. Therefore, using a mathematical transformation, we created new variables capturing intracomplex variation of both E and K. The values of these new compound variables were smaller for real complexes than for randomized ones. This shows that proteins in complexes tend to have closer expressivities (E) and K's simultaneously than in the randomly grouped genes. We speculate about the possible implications of this finding.

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Copyright

Copyright © 2007 Laurence Ettwiller and Reiner A. Veitia. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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