Research Article

Global Transcriptional Analysis of Yeast Cell Death Induced by Mutation of Sister Chromatid Cohesin

Table 3

List of differentially regulated genes response to stimulus in time point 1.

Response toGeneFold changeDescription
mcd1-1pds5-1

DNA damageRMI110.562.839.85Involved in response to DNA damage
RFX18.572.146.50Involved in DNA damage checkpoint pathway
EPL17.462.146.96Component of NuA4, a histone H4/H2A acetyltransferase complex
NTG16.962.307.46DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase
YKU806.962.147.46Subunit of the telomeric Ku complex (Yku70p-Yku80p)
NHP6A−4.00−2.00−2.30High-mobility group nonhistone chromatin protein

oxidative stressSRX121.113.739.19Sulfiredoxin
HSP1211.312.468.57Plasma membrane localized protein that protects membranes from desiccation
CTT110.564.9217.15Cytosolic catalase T
GRE38.572.4613.00Aldose reductase

HeatHSP2610.569.8529.86Small heat shock protein with chaperone activity
GRE38.572.4613.00Aldose reductase
SSA38.002.4612.13ATPase involved in protein folding and the response to stress
SSA48.002.1411.31Heat shock protein that is highly induced upon stress
SSE26.502.008.00Member of the heat shock protein 70 (HSP70) family
NTH213.932.0010.56Putative neutral trehalase

nutrition & othersALD319.7012.1351.98Cytoplasmic aldehyde dehydrogenase
PTR39.193.0312.13Component of the SPS plasma membrane amino acid sensor system
DDR28.576.5017.15Multistress response protein
FIG28.573.258.57Cell-wall adhesin
ADR18.573.039.85Carbon source-responsive zinc-finger transcription factor
YGP18.003.0310.56Cell-wall-related secretory glycoprotein
HAL17.462.836.50Cytoplasmic protein involved in halotolerance
TSL16.964.2913.93Large subunit of trehalose 6-phosphate synthase/phosphatase complex
MET46.502.469.19Lecine-zipper transcriptional activator
MPT56.502.009.19Member of the Puf family of RNA-binding proteins
PHO5−2.46−2.14−2.00Repressible acid phosphatase
TIR1−2.83−2.64−2.00Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins

UnknownYIL169C10.563.7327.86Putative protein of unknown function
YOR019W9.192.4610.56Hypothetical protein