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Comparative and Functional Genomics
Volume 2009, Article ID 354649, 16 pages
http://dx.doi.org/10.1155/2009/354649
Research Article

ATP-Binding Cassette Systems of Brucella

1Department of Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
2Départment de Microbiologie, Institut Pasteur, 25 rue Dr Roux, 75724 Paris Cedex 15, France
3FAO/WHO Collaborating Centre for Brucellosis, OIE Brucellosis Reference Centre, Veterinary Laboratories Agency, Addlestone, Surrey KT15 3NB, UK

Received 16 June 2009; Accepted 2 December 2009

Academic Editor: Graziano Pesole

Copyright © 2009 Dominic C. Jenner et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Brucellosis is a prevalent zoonotic disease and is endemic in the Middle East, South America, and other areas of the world. In this study, complete inventories of putative functional ABC systems of five Brucella species have been compiled and compared. ABC systems of Brucella melitensis 16M, Brucella abortus 9-941, Brucella canis RM6/66, Brucella suis 1330, and Brucella ovis 63/290 were identified and aligned. High numbers of ABC systems, particularly nutrient importers, were found in all Brucella species. However, differences in the total numbers of ABC systems were identified (B. melitensis, 79; B. suis, 72; B. abortus 64; B. canis, 74; B. ovis, 59) as well as specific differences in the functional ABC systems of the Brucella species. Since B. ovis is not known to cause human brucellosis, functional ABC systems absent in the B. ovis genome may represent virulence factors in human brucellosis.