Classification of Nonenzymatic Homologues of Protein Kinases

Table 8

Common and unique domain structures of PKLNKs and protein kinases encoded in the data set of genomes. Abbreviations followed in the table are Mad3_BUB1_I, Mad3/BUB1 homology region 1; Pkinase, Protein kinase; PKLNK, Protein kinase-like nonkinase; TM, Transmembrane; SH2, Src-homology 2; I-set, Immunoglobulin; Ank, Ankyrin; fn3, Fibronectin type III; Ephrin_lbd, Ephrin receptor ligand binding domain; SAM, Sterile alpha motif; HNOBA, Heme NO binding associated; Guanylate_cyc, Guanylate cyclase.

Domain structure unique to PKLNKs	Domain structure unique to protein kinases	Domain structure common to protein kinases and PKLNKs
PKLNK, HEAT × 2	TM, ANF_receptor, Pkinase, Guanylate_cyc	SH2, PKLNK, Pkinase
Ank × 2, PKLNK	I-set × 2, Pkinase	Recep_L_domain, Furin-like, Recep_L_domain, TM, PKLNK
TUDOR, PKLNK	Mad3_BUB1_I, Pkinase	PKLNK, Pkinase
ANF_receptor, TM, PKLNK, HNOBA, Guanylate_cyc	Ank × 3, Pkinase	TM, WSC, fn3, TM, PKLNK
		ANF_receptor, TM, PKLNK, Guanylate_cyc
		PKLNK, TBC, Rhodanese
		PKLNK, Guanylate_cyc
		TM, Ephrin_lbd, fn3 × 2, TM, PKLNK, SAM
		I-set × 18, fn3, I-set × 2, PKLNK, I-set, fn3, PKLNK
		TM, PKLNK, Guanylate_cyc
		SH2, PKLNK
		ANF_receptor, PKLNK, Guanylate_cyc
		PKLNK, TBC
		Ephrin_lbd, fn3 × 2, TM, PKLNK, SAM
		Death, PKLNK
		PX, PKLNK
		PKLNK, HEAT