An Exon-Based Comparative Variant Analysis Pipeline to Study the Scale and Role of Frameshift and Nonsense Mutation in the Human-Chimpanzee Divergence
Figure 2
Validation of the chimpanzee-specific frameshift mutation in CHIMP_X_139912 (cancer/testis antigen CT45): (I) sequence alignments between the human orthologous exon and three candidate seed sequences from chimpanzee-specific trace database (gn1 1278267, gn1 12291279, gn1 12291657). (II) sequence alignment between the chimpanzee exon and one of its candidate trace sequences. “!” represents frameshift mutations.
