Review Article

MicroRNA Profiling and Head and Neck Cancer

Table 2

Recently identified microRNA alterations in HNOC.

Profiling studyMethodsmicroRNA alterationsFunctional validation

Tran et al., 2007 [22] Profiling for 261 miRNAs was carried out on 9 HNOC cell lines. No normal control was included in this study. MicroarrayHigh expression in HNOC: miR-21, miR-23a, let-7f, miR-205, miR-31, let-7d, miR-221, let-7a, miR-320, miR-23b, miR-24, let-7c, miR-29b, miR-30b, miR-15a, miR-22, miR-107, miR-200b, miR-18, miR-16, miR-15b, miR-200a, miR-27a, let-7b, miR-28, hcv-miR-US33-1, miR-100, miR-98, miR-103, miR-125b, miR-361, miR-19a ā€‰
Low expression in HNOC: has-miR-345, miR-449, miR-302b, miR-382, miR-373, miR-378, miR-200c, miR-340, miR-302c, miR-154, miR-371, miR-127, miR-133a, miR-302d, miR-328, miR-212, miR-375, miR- , hcv-miR-US25-2-5p, miR-133b, miR-346, miR-342
Hebert et al., 2007 [23] Profiling for 260 miRNAs was carried out on 3 HNOC cell linescultured under normoxic ( ) or hypoxic conditions ( ).MicroarrayInduced by hypoxia: miR-572, miR-214, miR-563, miR-637, miR-98, miR-628, miR-191, miR-210, miR-31, miR-498, miR-373, miR-19a, miR-148a, miR-15a, miR-200a, miR-7, miR-30b, let-7e, let-7g, let-7i miR-98: regulates HMGA2 expression and chemosensitivity to doxorubicin and cisplatin.
Suppressed by hypoxia: miR-122a, miR-565, miR-195, miR-30e-5p, miR-374, miR-19a, miR-101, miR-424, miR-186, miR-29b, miR-148b, miR-141, miR-22, miR-331, miR-422b, miR-197
Chang et al., 2008 [24] Profiling for 314 miRNAs was carried out on 4 HNOC tissue samples (with 4 normal tissues as control). Concurrently, 4 HNOC cell lines and a normal oral keratinocyte cell line were also profiled.MicroarrayUpregulated in HNOC: miR-21, let-7, miR-18, miR-29c, miR-142-3p, miR-155, miR-146bmiR-21: regulates cell growth, cytochrome C release, and apoptosis.
Downregulated in HNOC: miR-494
Wong et al., 2008 [25, 26] Profiling for 156 miRNAs was carried out on 4 HNOC of tongue and 4 paired normal tissues. qRT PCRUpregulated in HNOC: miR-184, miR-34c, miR-137, miR-372, miR-124a, miR-21, miR-124b, miR-31, miR-128a, miR-34b, miR-154, miR-197, miR-132, miR-147, miR-325, miR-181c, 198, miR-155, miR-30a-3p, miR-338, miR-17-5p, miR-104, miR-134, miR-213.miR-184: regulates proliferation, c-Myc expression, and apoptosis. miR-133a/133b: regulate proliferation, apoptosis, and PKM2 expression.
Downregulated in HNOC: miR-133a, miR-99a, miR-194, miR-133b, miR-219, miR-100, miR-125b, miR-26b, miR-138, miR-149, miR-195, miR-107, miR-139.
Kozaki et al., 2008 [27] Profiling for 148 miRNAs was carried out on 18 HNOC cell lines. One immortalized oral keratinocyte line was used as control.qRT PCRUpregulated in HNOC: miR-374, miR-340, miR-224, miR-10a, miR-140, miR- , miR-146a, miR-126, miR-31, miR-9, miR- .miR-137: regulates cell growth and CDK6 expression. miR-193a: regulates cell growth and E2F6 expression.
Downregulated in HNOC: miR-27a, miR-34b, miR-34c, miR-203, miR- , miR-23a, miR-27b, miR-34a, miR-215, miR-299, miR-330, miR-337, miR-107, miR-133b, miR-138, miR-139, miR-223, miR-204, miR-370, let-7d, miR-95, miR-302a, miR-367, let-7g, miR-23b, miR-128a, miR-148a, miR-155, miR-200c, miR-302b, miR-368, miR-122a, miR-371, let-7a, miR-26b, miR-30e-5p, miR-96, miR-125a, miR-132, miR-200b, miR-199b, miR-296, miR- , miR-137, miR-197, miR-193a, let-7e, miR-30d, miR-331, miR-342, miR-338, miR-199a, miR-372, miR-184