Comparative Analyses of Transcriptional Profiles in Mouse Organs Using a Pneumonic Plague Model after Infection with Wild-Type Yersinia pestis CO92 and Its Braun Lipoprotein Mutant

Table 1

Summary of altered gene expression in mice infected with WT Y. pestis CO92, or its Δlpp mutant, compared to uninfected control animals.

Tissue	Control versus WT				WT versus Mutant
	12 hours		48 hours		12 hours		48 hours
	Up	Down	Up	Down	Up	Down	Up	Down
	Number of Genes
Liver	33	39	966	441	5	6	120	136
Lung	37	10	162	30	—	—	109	—
Spleen	44	4	77	1	9	16	—	—

A dash (“—") indicates that no gene expression differences were deemed as statistically significant (fold-change ≥1.5, 𝑃 value ≤.05). Note that ∼57% (109 out of 192) of WT Y. pestis-induced host transcriptional responses in the lungs of mice infected for 48 hours were perturbed in the absence of lpp.