Comparative Analyses of Transcriptional Profiles in Mouse Organs Using a Pneumonic Plague Model after Infection with Wild-Type Yersinia pestis CO92 and Its Braun Lipoprotein Mutant

Table 3

Comparison of transcriptional alterations in mice infected with WT Y. pestis CO92 (this study) and a strain that is avirulent in humans (Y. pestis strain 201, previous study reported by Liu et al. [21]).

This study			Liu et al.
Gene	FC	Tissue	Gene	FC	Tissue
CD34	3.7	Liver	CD34	2.2	Liver
Ifitm1	3.3	All	Ifitm3	2.7	Liver
Ifitm6	4.4	Lung
Tgfbr2	2.3	Liver	Tgfb3	2.5	Liver
				−3	Lung
Tnfsf10	2.3	Liver	Tnfrsf1a	2.3	Liver
			Tnfrsf13b	2.3	Lung
Ccl20	2.4	Lung	Ccl20	7.5	Lung
Cd14	12.5	All	Cd14	14.1	Lung & Liver
Csf3	6.6	All	Csf3	5	Lung
Cxcl2	39.8	Lung & Liver	Cxcl2	14.2	Lung & Liver
Cxcl5/6	9.5	All	Cxcl5/6	2.6	Lung
IL-1b	5.6	All	IL-1b	4.8	Lung
IL2rg	2.9	Liver	IL2rb	2.5	Lung
Tnfaip8	2	Liver	Tnfaip8	2.3	Lung
Cd9	2.8	Liver	Cd9	2.4	Liver
				−2.6	Lung
Icam2	2.8	Liver	Icam2	1.9	Liver
				−3.1	Lung
IFN-𝛾	4.6	All	IFN-𝛾	−2.2	Lung
Igfbp1	3.7	Liver	Igfbp1	3.2	Liver
			Igfbp4	2.1
Lbp	4.2	Liver	Lbp	4.2	Liver
Ndrg	−2	Liver	Ndrg1	Up	?
Gadd45g	8.3	Liver	Gadd45g	Up	?
MT1	5.1	Lung & Liver	MT1	Up	Lung & Liver
MT2	9.2	Lung & Liver	MT2	Up	Lung & Liver

For this study, fold changes (FCs) shown are averages across affected tissues. Only alterations that were determined to be statistically significant (i.e., Benjamini and Hochberg corrected 𝑃 value <.05 and absolute consistency across all replicate experiments) are included. A negative sign before values indicates downregulation.