In Vivo Cytogenetic Studies on Aspartame

Table 1

Total chromosomal aberration in mouse bone marrow following exposure of aspartame.

Treatment	Chromosomal aberrations/250 cells
(mg/kg body weight)	G^′	G	B^′	B	DC ± SD	CA/Cell ± SD
Control	5	0	5	0	0.02 ± 0.00	0.02 ± 0.00
3.5	3	0	5	0	0.02 ± 0.01^ns	0.02 ± 0.00^ns
35	7	1	8	1	0.04 ± 0.01**	0.04 ± 0.01**
350	8	0	11	0	0.05 ± 0.01**	0.05 ± 0.01**

G^′, G = chromatid and chromosome gaps; B^′, B = chromatid and chromosome breaks; DC = damaged cells with at least one CA (excluding gaps); CA = chromosomal aberrations; SD = standard deviation of the mean; * significant with both control and 3.5 mg/kg body weight at level 0.01; ^ns not significant with vehicle control.