In Vivo Cytogenetic Studies on Aspartame

Table 3

Frequency of SCE and MI in mouse bone marrow following exposure of aspartame.

Treatment (mg/kg body weight)	Min-Max SCE	SCE/cell ± SE	MI ± SE
Control	0–17	3.20 ± 0.73	2.80 ± 0.37
3.5	3–10	4.60 ± 0.40	2.20 ± 0.37
35	3–15	4.40 ± 0.81	2.00 ± .0.55
350	3–20	5.40 ± 0.93	2.00 ± 0.32

A total 150 cells were scored for the SCE assay; 1000 cells from each animal were scored for MI.