Research Article
Applications of Different Weighting Schemes to Improve Pathway-Based Analysis
Table 9
Top 33 type II diabetes pathways selected in the random forests under uniform weight and RWM scheme.
| Index | Uniform weight | RWM scheme | Rank | PID | No. of genes | OOB (%) | Rank | PID | No. of genes | OOB (%) |
| 1 | 1 | 79 | 33 | 0.26 | 1 | 140 | 22 | 0.11 | 2 | 2 | 4 | 18 | 0.29 | 2 | 113 | 26 | 0.14 | 3 | 2 | 140 | 22 | 0.29 | 2 | 192 | 1 | 0.14 | 4 | 4 | 36 | 116 | 0.31 | 4 | 106 | 5 | 0.17 | 5 | 4 | 124 | 4 | 0.31 | 5 | 117 | 26 | 0.17 | 6 | 4 | 230 | 121 | 0.31 | 4 | 144 | 7 | 0.17 | 7 | 7 | 5 | 6 | 0.34 | 4 | 163 | 8 | 0.17 | 8 | 7 | 16 | 49 | 0.34 | 4 | 164 | 26 | 0.17 | 9 | 7 | 32 | 157 | 0.34 | 4 | 176 | 3 | 0.17 | 10 | 7 | 46 | 36 | 0.34 | 4 | 197 | 11 | 0.17 | 11 | 7 | 51 | 185 | 0.34 | 4 | 235 | 3 | 0.17 | 12 | 7 | 109 | 91 | 0.34 | 4 | 244 | 46 | 0.17 | 13 | 7 | 141 | 4 | 0.34 | 4 | 245 | 11 | 0.17 | 14 | 7 | 229 | 133 | 0.34 | 4 | 250 | 12 | 0.17 | 15 | 7 | 267 | 4 | 0.34 | 4 | 251 | 1 | 0.17 | 16 | 16 | 1 | 2 | 0.37 | 4 | 254 | 25 | 0.17 | 17 | 16 | 6 | 3 | 0.37 | 4 | 274 | 16 | 0.17 | 18 | 16 | 11 | 15 | 0.37 | 4 | 275 | 9 | 0.17 | 19 | 16 | 13 | 92 | 0.37 | 19 | 1 | 2 | 0.20 | 20 | 16 | 37 | 235 | 0.37 | 19 | 4 | 18 | 0.20 | 21 | 16 | 40 | 240 | 0.37 | 19 | 5 | 6 | 0.20 | 22 | 16 | 49 | 188 | 0.37 | 19 | 11 | 15 | 0.20 | 23 | 16 | 59 | 194 | 0.37 | 19 | 24 | 14 | 0.20 | 24 | 16 | 76 | 3 | 0.37 | 19 | 42 | 2 | 0.20 | 25 | 16 | 144 | 7 | 0.37 | 19 | 52 | 122 | 0.20 | 26 | 16 | 162 | 2 | 0.37 | 19 | 69 | 20 | 0.20 | 27 | 16 | 173 | 11 | 0.37 | 19 | 74 | 1 | 0.20 | 28 | 16 | 194 | 13 | 0.37 | 19 | 78 | 6 | 0.20 | 29 | 16 | 201 | 19 | 0.37 | 19 | 80 | 5 | 0.20 | 30 | 16 | 207 | 3 | 0.37 | 19 | 85 | 8 | 0.20 | 31 | 16 | 209 | 21 | 0.37 | 19 | 86 | 39 | 0.20 | 32 | 16 | 227 | 13 | 0.37 | 19 | 98 | 71 | 0.20 | 33 | 16 | 228 | 43 | 0.37 | 19 | 99 | 13 | 0.20 |
| Total | | | 2050 | 11.29 | | | 578 | 5.86 | Average | | | 64 | 0.35 | | | 18 | 0.18 |
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