High Levels of Sequence Diversity in the 5′ UTRs of Human-Specific L1 Elements

Table 1

Average frequency of substitutions across the promoter and TF binding sites of the L1 5′ UTR.

Region	Active L1 elements (%)	Dead L1 elements (%)	All L1 elements in the human genome (%)
Sense promoter	0.66	0.99	2.14
YY1	0.15	0.27	1.38
Runx3	0.00	0.26	0.53
SRY-1	0.00	0.49	0.81
Runx3 ASP	0.29	0.26	0.86
SRY-2	0.00	0.00	0.41
5′ UTR overall	0.53	0.78	1.62