Empirical Bayes Model Comparisons for Differential Methylation Analysis
Figure 1
Model performance comparisons in differential methylation data analysis. Five empirical Bayes models were compared: (1) binary-gamma-gamma (BGG); (2) binary-normal-gamma-gamma (BNGG); (3) binary-normal-normal-gamma-gamma (BNNGG); (4) binary-log-normal-normal (BLNN); (5) binary-log-normal-normal-normal (BLNNN). Negative log-likelihoods (a) and the number of identified differentially methylated CpG islands (b) of the five Bayesian models as applied for comparing methylation differences between A2780 parental cells and their cisplatin-treated 1st, 3rd, and 5th generation daughter cells.
