Review Article

Before It Gets Started: Regulating Translation at the 5′ UTR

Figure 3

Impact of uAUG sequences on translation regulation. (a) Comparison of luciferase levels obtained for constructs having the 5′ UTR of the gene ACT (control) and genes containing uAUG: WBSCR16, MFSD5, and BCL2L13. (b) Deletion or mutation of uAUG sequence present in genes WBSCR16, MFSD5 and BCL2L13 reverts translation repression as seen as an increase in luciferase activity.
475731.fig.003a
(a)
475731.fig.003b
(b)