Cytoplasmic Ribonucleoprotein Foci in Eukaryotes: Hotspots of Bio(chemical)Diversity

Figure 2

Relationship among active polysomes and PBs. The recruitment of active polysomes to PB implies the removal from the mRNA of the translation factors by translational repressors. Some of them have been demonstrated to interact with eIF4E in vivo (rck/p54 and eIF4E-T, [16]). They further interact and/or recruit the enhancers of decapping Lsm1-7 or the miRNA-related protein GW182 to form the PB. Later on, they assemble the decapping and degradation enzymes and/or the proteins required for silencing and storage into PB. All the intermediate steps of this process can represent different populations of granules coexisting in the cell and visible with different morphology that might reflect a variety of components and/or diverse stoichiometry.