The α₁AT and TIMP-1 Gene Polymorphism in the Development of Asthma

Table 3

Distribution of genotype frequencies of SNPs of α ₁AT and TIMP-1 genes in asthma patients and control group.

SNP	Patients	Control	𝜒^2	* P value	OR (95% CI)^†
Allele	(n = 202)	(n = 204)
Val213Ala (𝛼1AT)
(rs6647)
TT	152 (75.24%)	167 (81.80%)			1
TC	46 (22.77%)	34 (16.67%)	2. 48	0.12	1.21 (0.97–1.51)
CC	4 (1.98%)	3 (1.40%)	0.25	0.62	1.20 (0.63–2.30)
Glu363Lys (𝛼1AT)
(Novel)
GG	135 (66.83%)	171 (83.80%)			1
GA	51 (25.24%)	26 (12.74%)	12.05	0.001	1.50 (1.23–1.84)
AA	16 (7.92%)	7 (3.43%)	5.58	0.02	1.58 (1.17–2.13)
Glu376Asp (𝛼1AT)
(rs1303)
AA	127 (62.87%)	140 (68.63%)			1
AC	54 (26.73%)	51 (25.00 %)	0.45	0.50	1.08 (0.86–1.35)
CC	21 (10.39%)	13 (6.37%)	2.43	0.12	1.29 (0.97–1.74)
rs5953060 (TIMP-1)
CC	33 (30.27%)	26 (33.33%)			1
CG	43 (39.45%)	31 (39.74 %)	0.06	0.80	1.04 (0.77–1.39)
GG	33 (30.27%)	21 (26.92%)	0.31	0.58	1.09 (0.80–1.49)
C	48 (51.61%)	71 (56.34%)
G	45 (48.38%)	55 (43.65%)	0.48	0.49	0.67 (0.43–1.07)
Base 3774 (TIMP-1)
GG	80 (73.39%)	74 (94.87%)			1
GA	23 (21.10%)	3 (3.84%)	12.12	0.001	1.70 (1.39–2.09)
AA	6 (5.50%)	1 (1.28%)	3.07	0.07	1.65 (1.18–2.32)
G	82 (88.17%)	120 (95.23%)
A	11 (11.83%)	6 (4.76%)	3.73	0.05	1.59 (1.08–2.35)
rs4898 Phe124Phe (TIMP-1)
TT	37 (33.94%)	40 (51.28%)			1
TC	42 (38.53%)	29 (37.17%)	1.83	0.18	1.23 (0.91–1.66)
CC	30 (27.52%)	9 (11.53%)	8.84	0.002	1.60 (1.19–2.14)
T	49 (52.69%)	84 (63.49%)
C	44 (47.31%)	42 (33.33%)	4.57	0.03	1.39 (1.03–1.89)
rs6609533 (TIMP-1)
GG	46 (42.20%)	39 (50.00%)			1
GA	35 (32.11%)	26 (33.33%)	0.15	0.69	1.06 (0.79–1.42)
AA	28 (25.69%)	13 (16.67%)	2.29	0.13	1.26 (0.95–1.68)
G	61 (65.60%)	85 (67.46%)
A	32 (34.40%)	41 (32.53%)	0.08	0.77	1.05 (0.76–1.45)
rs11551797 Ile158Ile (TIMP-1)
CC	107 (98.16%)	74 (94.87%)			1
CT	2 (1.83%)	3 (3.84%)	0.73	0.39	0.68 (0.23–1.99)
TT	0 (0.00%)	1 (1.36%)			N/A
C	91 (97.84%)	121 (96.03%)
T	2 (2.15%)	5 (3.96%)	0.57	0.45	0.67 (0.20–2.17)
rs2070584 (TIMP-1)
GG	33 (30.27%)	33 (42.30%)			1
GT	46 (42.20%)	27 (34.61%)	2.39	0.12	1.26 (0.94–1.69)
TT	30 (27.52%)	18 (23.07%)	1.76	0.19	1.35 (0.86–2.12)
G	48 (51.61%)	78 (61.90%)
T	45 (48.38%)	48 (38.09%)	2.32	0.13	1.27 (0.94–1.73)
rs2070534 (TIMP-1)
AA	34 (31.19%)	27 (34.61%)			1
AG	47 (43.12%)	34 (43.58%)	2.64	0.10	1.31 (0.94–1.84)
GG	28 (25.69%)	17 (21.79%)	3.35	0.07	1.41 (0.98–2.02)
A	50 (53.76%)	81 (64.28%)
G	43 (46.23%)	45 (35.71%)	2.47	0.12	1.28 (0.94–1.74)

* P values were obtained after adjusting it with age, BMI, and SI by regression analysis using SPSS 12 software.
^†OR (95% CI): odds ratio (95% confidence interval). Genotype frequencies of male and female individuals for TIMP-1 are given separately, since only single allele exists in male individuals.