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Comparative and Functional Genomics
Volume 2012, Article ID 979168, 8 pages
Review Article

Tackling Skeletal Muscle Cells Epigenome in the Next-Generation Sequencing Era

Department of Biomolecular Sciences and Biotechnology, University of Milano, Via Celoria 26, 20133 Milan, Italy

Received 3 February 2012; Accepted 3 April 2012

Academic Editor: Lucia Latella

Copyright © 2012 Raffaella Fittipaldi and Giuseppina Caretti. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Recent advances in high-throughput technologies have transformed methodologies employed to study cell-specific epigenomes and the approaches to investigate complex cellular phenotypes. Application of next-generation sequencing technology in the skeletal muscle differentiation field is rapidly extending our knowledge on how chromatin modifications, transcription factors and chromatin regulators orchestrate gene expression pathways guiding myogenesis. Here, we review recent biological insights gained by the application of next-generation sequencing techniques to decode the epigenetic profile and gene regulatory networks underlying skeletal muscle differentiation.