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International Journal of Genomics
Volume 2013, Article ID 383024, 12 pages
http://dx.doi.org/10.1155/2013/383024
Research Article

A Complex Network of MicroRNAs Expressed in Brain and Genes Associated with Amyotrophic Lateral Sclerosis

Functional Genomics and Gene Silencing Group, Centre for Cellular and Molecular Biology, Hyderabad 500007, India

Received 10 January 2013; Accepted 5 June 2013

Academic Editor: John Parkinson

Copyright © 2013 Santosh Shinde et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Table S1: Information of Amyotrophic Lateral Sclerosis Disease associated genes selected from KEGG pathway database.

Table S2: Distribution of target sites predicted across gene in 5' UTR, CDS and 3' UTR for miRNAs expressed in midbrain, cerebellum, frontal cortex and hippocampus predicted by miRanda.

Table S3: Target sites predicted for miRNAs expressed in midbrain, cerebellum, hippocampus and frontal cortex using TargetScan.

Table S4: Target sites predicted for miRNAs expressed in midbrain, cerebellum, hippocampus and frontal cortex using Pictar.

Table S5: Comparison of target site prediction results obtained using TargetScan and Pictar.

Table S6: Comparison of target site prediction results obtained using miRanda and Pictar.

Table S7: Hot spots identified in selected genes in 5'UTR , CDS and 3' UTR for miRNAs considered in the study.

Figure SF1: Schematic representation of miRNA Target sites on ALS2

Figure SF2: Schematic representation of miRNA Target sites on APAF1

Figure SF3: Schematic representation of miRNA Target sites on BAD

Figure SF4: Schematic representation of miRNA Target sites on BAX

Figure SF 5: Schematic representation of miRNA Target sites on BCL2

Figure SF 6: Schematic representation of miRNA Target sites on BCL2L1

Figure SF7: Schematic representation of miRNA Target sites on BID

Figure SF8: Schematic representation of miRNA Target sites on CASP1

Figure SF8: Schematic representation of miRNA Target sites on CASP1

Figure SF9: Schematic representation of miRNA targets on GRIA1

Figure SF10: Schematic representation of miRNA Target sites on GPX1

Figure SF11: Schematic representation of miRNA Target sites on DERL1

Figure SF12: Schematic representation of miRNA Target sites on DAXX

Figure SF13: Schematic representation of miRNA Target sites on CYCS

Figure SF14. Schematic representation of miRNA targets on CHP

Figure SF15: Schematic representation of miRNA Target sites on CCS

Figure SF16: Schematic representation of miRNA Target sites on CAT

Figure SF17: Schematic representation of miRNA Target sites on CASP9

Figure SF18: Schematic representation of miRNA Target sites on CASP3

Figure SF19: Schematic representation of miRNA Target sites on TOMM40

Figure SF20: Schematic representation of miRNA Target sites on TNFRSF1A

Figure SF21: Schematic representation of miRNA Target sites on TNF

Figure SF22: Schematic representation of miRNA Target sites on SOD1

Figure SF23: Schematic representation of miRNA Target sites on SLC1A2

Figure SF24: Schematic representation of miRNA Target sites on RAC1

Figure SF25: Schematic representation of miRNA Target sites on RAB5A

Figure SF26: Schematic representation of miRNA Target sites on p53

Figure SF27: Schematic representation of miRNA Target sites on NOS1

Figure SF28: Schematic representation of miRNA Target sites on NEFM

Figure SF29: Schematic representation of miRNA targets on NEFL

Figure SF30: Schematic representation of miRNA Target sites on NEFH

Figure SF31: Schematic representation of miRNA Target sites on MAPK14

Figure SF32: Schematic representation of miRNA Target sites on MAP3K5

Figure SF33: Schematic representation of miRNA Target sites on MAP2K6

Figure SF34: Schematic representation of miRNA Target sites on MAP2K3

Figure SF35: Schematic representation of miRNA Target sites on PRPH

Figure SF36: Schematic representation of miRNA conserved target on BCL2

Figure SF37: Schematic representation of miRNA conserved target on MAP2K3

  1. Supplementary Materials