TSP-1-1223 A/G Polymorphism as a Potential Predictor of the Recurrence Risk of Bladder Cancer in a Chinese Population
Table 3
Stratification analyses between TSP-1-1223 A/G polymorphism and risk of bladder cancer.
Variables
Genotypes (cases/controls)
Cases/controls
AA + AG
GG
Crude OR (95% CI)
Adjusted OR (95% CI)b
%
%
Total
Age (year)
<65
289/331
243/289
84.1/87.3
46/42
15.9/12.7
0.251
1.30 (0.81–2.10)
0.128
1.38 (0.86–2.25)
≥65
320/339
289/303
90.3/89.4
31/36
9.7/10.6
0.692
0.90 (0.53–1.55)
0.719
0.94 (0.55–1.61)
Sex
Male
484/506
423/457
87.4/90.3
61/49
12.6/9.7
0.144
1.34 (0.89–2.05)
0.127
1.39 (0.91–2.13)
Female
125/164
109/135
87.2/82.3
16/29
12.8/17.7
0.257
0.68 (0.33–1.38)
0.495
0.78 (0.38–1.60)
Smoking status
Never
317/426
278/377
87.7/88.5
39/49
12.3/11.5
0.738
1.08 (0.67–1.73)
0.381
1.25 (0.76–2.05)
Ever
292/244
254/215
86.6/88.1
38/29
13.4/11.9
0.694
1.11 (0.64–1.93)
0.747
1.10 (0.63–1.91)
Drinking status
No
418/482
367/423
87.8/87.8
51/59
12.2/12.2
0.986
1.00 (0.65–1.52)
0.644
1.11 (0.71–1.73)
Yes
191/188
165/169
86.4/89.9
26/19
13.6/10.1
0.291
1.40 (0.71–2.79)
0.396
1.34 (0.68–2.64)
Family history of cancer
No
440/622
385/547
87.5/87.9
55/75
12.5/12.1
0.829
1.04 (0.70–1.53)
0.558
1.12 (0.76–1.65)
Yes
169/48
147/45
87.0/93.7
22/3
13.0/6.3
0.195
2.24 (0.63–12.2)
0.284
2.02 (0.56–7.26)
CI: confidence interval; OR: odds ratio. Two-sided test for either genotype distributions or allele frequencies between the cases and controls.
bAdjusted for age, gender, smoking, drinking status, and family history of cancer in logistic regression model.
