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International Journal of Genomics
Volume 2013, Article ID 609748, 10 pages
Research Article

DUSP1 Gene Polymorphisms Are Associated with Obesity-Related Metabolic Complications among Severely Obese Patients and Impact on Gene Methylation and Expression

1Institute of Nutrition and Functional Foods (INAF), Laval University, Québec, QC, Canada G1V 0A6
2Department of Food Science and Nutrition, Laval University, Québec, QC, Canada G1V 0A6
3Endocrinology and Nephrology, CHU de Québec Research Center, Québec, QC, Canada G1V 4G2
4Department of Biochemistry, Université de Sherbrooke, ECOGENE-21, Chicoutimi Hospital, Saguenay, Canada G7H 7P2
5Department of Medicine, Laval University, Québec, QC, Canada G1V 0A6
6Québec Heart and Lung Institute, Québec, QC, Canada G1V 4G5
7Department of Surgery, Laval University, Québec, QC, Canada G1V 0A6
8Department of Kinesiology, Laval University, Québec, QC, Canada G1V 0A6

Received 3 May 2013; Accepted 11 July 2013

Academic Editor: Sinan Tanyolaç

Copyright © 2013 F. Guénard et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Table 1. Validation of microarray results by real-time PCR for the DUSP1 gene.

Supplementary Table 2. Potential impact of CVD-associated promoter SNPs on transcription factor binding sites.

Supplementary Table 3. List of CpG sites analyzed with corresponding localization.

Supplementary Figure 1. Schematic representation of sequence-derived SNPs at the DUSP1 locus (chromosome 5q34).

  1. Supplementary Material