Review Article

MicroRNAs in the Neural Retina

Table 1

Differentially expressed microRNAs in retina related disorders in human and animal models.

MicroRNAOrganismRetinal disorderRefs

miR-9, miR-125b, miR-146a, miR-155 

miR-24
Human 

Endothelial cells (EC)
Age-related macular degeneration[21, 22] 

[22]
miR-126, miR-146, miR-200b, miR-146a, miR-182, miR-96, miR-183, miR-211, miR-204, and miR-124, miR-10b, miR-10a, miR-219-2-3p, miR-144, miR-338 and miR-199a-3pRatDiabetic retinopathy[2327]
miR-365b-3p, miR-17, miR-18a, and miR-20, let-7 

miR-376a
Human  

Retinoblastoma cells
Retinoblastoma[3133]  

[34]
miR-1, miR-133, miR-96, miR-183, miR-376, miR-691 

miR-146a, miR-146b-5p
Mouse  

Human RPE cells
Retinitis pigmentosa[28, 29]  

[30]
miRNA-183/96/182 clusterMouse Retinal degeneration[35]
miRNA-34aRPE cellsInhibits proliferation and migration of RPE cells[79]
miR-150 and miR-200cHuman embryonic stem (hES) cell 

Chick embryos
Endothelial cell differentiation 

Blood vessel formation
[40]
miR-126MouseReduce ischemia-induced retinal NV[27]