Research Article
A Promoter Region Polymorphism in PDCD-1 Gene Is Associated with Risk of Rheumatoid Arthritis in the Han Chinese Population of Southeastern China
Table 4
Estimated haplotype frequencies and the association analysis with RA.
| Haplotype | Sequence | Cases | Controls | Total | OR (95% CI) | value |
| 1 | ATC | 0.4108 | 0.4061 | 0.4081 | 1.00 | — | 2 | GCC | 0.2583 | 0.1919 | 0.2248 | 1.28 (0.94–1.73) | 0.11 | 3 | GCT | 0.2127 | 0.2066 | 0.2098 | 0.98 (0.72–1.32) | 0.87 | 4 | GTC | 0.0523 | 0.0462 | 0.0497 | 1.04 (0.53–2.02) | 0.91 | 5 | ACT | 0.019 | 0.0821 | 0.0463 | 0.23 (0.10–0.53) | | 6 | ACC | 0.0138 | 0.0420 | 0.0280 | 0.32 (0.11–0.96) | 0.043* | 7 | ATT | 0.0269 | 0.0139 | 0.0210 | 1.61 (0.52–5.02) | 0.41 | Rare | — | — | — | 0.0081 | 1.55 (0.27–8.96) | 0.68 | | Global haplotype association P value: 0.0015* |
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OR: odds ratio; 95% CI: 95% confidence intervals.. Rare haplotypes were pooled together in a group.
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