Research Article
Genetic Polymorphisms of Interleukin-1 Alpha and the Vitamin D Receptor in Mexican Mestizo Patients with Intervertebral Disc Degeneration
Table 2
Allelic (af) and genotype (gf) frequencies of IL1A and VDR polymorphisms in controls subjects and patients with IDD.
| SNPs | Patients | Controls | () | () |
| rs1800587 (IL1A) | | | | |
| Alleles | | af | | af |
| T | 53 | 0.27 | 55 | 0.28 | C | 147 | 0.74 | 145 | 0.73 |
| Genotypes | | gf | | gf |
| TT | 4 | 0.04 | 10 | 0.10 | CT | 45 | 0.45 | 35 | 0.35 | CC | 51 | 0.51 | 55 | 0.55 |
| rs2228570 (VDR) | | | | |
| Alleles | | af | | af |
| V | 105 | 0.53 | 115 | 0.58 | T | 95 | 0.48 | 85 | 0.43 |
| Genotypes | | gf | | gf |
| VV | 20 | 0.20 | 32 | 0.32 | TV | 65 | 0.65 | 51 | 0.51 | TT | 15 | 0.15 | 17 | 0.17 |
| rs731236 (VDR) | | | | |
| Alleles | | af | | af |
| C | 35 | 0.18 | 41 | 0.21 | T | 165 | 0.83 | 159 | 0.80 |
| Genotypes | | gf | | gf |
| CC | 4 | 0.04 | 3 | 0.03 | TC | 27 | 0.27 | 35 | 0.35 | TT | 69 | 0.69 | 62 | 0.62 |
|
|