Lack of Association of the Polymorphisms IL-17A (−197G/A) and IL-17F (+7488A/G) with Multibacillary Leprosy in Mexican Patients
Table 2
Allelic and gene frequencies of polymorphisms in IL-17A and IL-17F genes in subclinical forms (LL and D) and healthy controls.
D patients (%)
CS (%)
OR (95% CI)
a value
LL patients (%)
OR (95% CI)
b value
OR (95% CI)
c value
Genotype
IL-17A −197
GG
7 (88)
29 (42)
—
—
31 (52)
—
—
—
—
GA
1 (12)
40 (58)
0.10 (0–0.93)
0.038
29 (48)
1.47 (0.69–3.14)
0.358
0.15 (0.01–1.38)
0.123
AA
0 (0)
0 (0)
0 (0)
GA + AA
1 (12)
40 (58)
0.10 (0–0.93)
0.038
29 (48)
1.47 (0.69–3.14)
0.358
0.15 (0.01–1.38)
0.123
IL-17F +7488
AA
7 (78)
52 (76)
—
—
51 (82)
—
—
—
—
AG
2 (22)
16 (24)
1.08 (0.17–8.38)
0.739
11 (18)
1.43 (0.56–3.67)
0.551
1.32 (0.16–8.64)
0.891
GG
0 (0)
0 (0)
0 (0)
AG + GG
2 (22)
16 (24)
1.08 (0.17–8.38)
11 (18)
1.43 (0.56–3.67)
0.551
1.32 (0.16–8.64)
0.891
Allele
IL-17A −197
G
15 (94)
98 (71)
6.12 (0.80–1228)
0.039
91 (76)
0.21 (0.01–1.63)
0.192
1.28 (0.71–2.32)
0.464
A
1 (6)
40 (29)
29 (24)
IL-17F +7488
A
16 (89)
120 (88)
1.07 (0.20–7.39)
0.757
113 (91)
1.28 (0.0–7.08)
0.897
1.37 (0.57–3.32)
0.575
G
2 (11)
16 (12)
11 (9)
The values are presented as frequency in percentage (%) and number () of genotypes or alleles. The frequencies comparison between groups was analyzed by Chi-square test. Statistical significance was at Yates corrected; OR, odds ratio; CI, confidence interval; , number of individuals; MB, multibacillary leprosy; CS, healthy controls; D, dimorphic; LL, lepromatous leprosy. aD patients versus CS; bLL versus CS; cD versus LL.
