Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation
Table 2
Examples of relief from miRNA-mediated downregulation.
miRNA
Target mRNA
Expression regulation
Reference
miR-122
CAT-1
In response to amino acid starvation, HuR binding to 3′UTR interferes with miRNP association with CAT-1 mRNA and results in relocalization of mRNP from P bodies in the cytoplasm to polysomes.
The loss of the interdependent binding between HuR and miR-19 to the RhoB mRNA upon UV exposure relieves this mRNA from miR-19-dependent inhibition of translation.
HuR enhances TOP2A translation by antagonizing with miR-548c-3p. Their combined actions control TOP2A expression levels and determine the effectiveness of doxorubicin.
Gain of function mutation in LRRK2 makes it more associable to dAGO1 and LRRK2 kinase which phosphorylates 4E-BP1 and consequently associates with hAGO2 which counteracts with miRNA mediated repression.