Genomic Changes in an Attenuated ZB Strain of Foot-and-Mouth Disease Virus Serotype Asia1 and Comparison with Its Virulent Parental Strain

Table 4

Synonymous nucleotides substitutions in the protein coding region between the virulent and attenuated ZB strains.

Region	Position*	Virulent strains^†	Attenuated strains^†
L^pro	1339	GCA	GCG
	1421	CTG	TTG
	1630	GTG	GTA
VP4	1807	CAG	CAA
VP2	2074	GAC	GAT
	2263	GGC	GGG
	2575	GTA	GTG
VP3	2980	GTG	GTA
	3019	GTG	GTA
	3076	TCT	TCC
	3169	ATT	ATC
VP1	3691	CGT	CGC
2B	4132	CTC	CTT
2C	4684	GCT	GCC
	4918	TTC	TTT
	5029	CTA	CTG
3A	5377	CAG	CAA
3B	6085	CCT	CCC
	6346	GAC	GAT
3D^pol	7006	GAG	GAA
	7417	TGC	TGT

The nucleotides listed are at equivalent positions of ZB/CHA/58(att) (GenBank number DQ533483). Nucleotide changes are indicated in bold.
^†The virulent FMDV ZB strains included ZBCF22 and YNBS/58, and the attenuated strains included ZBRF168, ZBRF188, and ZB/CHA/58(att).