Genetics of Human and Canine Dilated Cardiomyopathy

Table 2

All genes investigated in relation to canine DCM.

Gene	Associated with DCM in humans	Associated with canine DCM	DCM dogs		Control dogs	Human reference	Canine study reference
			Number	Breed
ACTC1	Y	N	16	Doberman Pinscher	12 mixed breeds	[39, 142]	[77]
			64	Irish Wolfhound	25 Irish Wolfhounds		[143]
			38	Newfoundland	36 Newfoundlands		[69]
			5	Doberman Pinscher	5 unspecified dogs without overt heart disease		[144]
ACTN2	Y	N	5	Doberman Pinscher	5 unspecified dogs without overt heart disease	[39, 142]	[144]
CAV1	N	N	38	Newfoundland	36 Newfoundlands	na	[69]
CSRP3	Y	N	64	Irish Wolfhound	25 Irish Wolfhounds	[39, 142]	[143]
			38	Newfoundland	36 Newfoundlands		[69]
			5	Doberman Pinscher	2 Labradors		[67]
			5	Doberman Pinscher	5 unspecified dogs without overt heart disease		[144]
DES	Y	N	25	Doberman Pinscher	10 Doberman Pinschers	[39, 142]	[35]
			64	Irish Wolfhound	25 Irish Wolfhounds		[143]
			18	Doberman Pinscher	10 Doberman Pinschers		[68]
			38	Newfoundland	36 Newfoundlands		[69]
DMD	Y	Y	2	German short-haired pointers	2 German short-haired pointers with reduced dystrophin	[39, 142]	[63]
LDB3	Y	N	38	Newfoundland	36 Newfoundlands	[39, 142]	[69]
LMNA	Y	N	38	Newfoundland	36 Newfoundlands	[39, 142]	[69]
			5	Doberman Pinscher	2 Labradors		[67]
MYBPC3	Y	N	5	Doberman Pinscher	5 unspecified dogs without overt heart disease	[39, 142]	[144]
MYH7	Y	N	38	Newfoundland	36 Newfoundlands	[39, 142]	[69]
			5	Doberman Pinscher	2 Labradors		[67]
			5	Doberman Pinscher	5 unspecified dogs without overt heart disease		[144]
PDK4	N	Y	66	Doberman Pinscher	66 Doberman Pinschers + 100 others from 11 breeds	na	[60]
PLN	Y	N	25	Doberman Pinscher	10 Doberman Pinschers	[39, 142]	[35]
			2 Doberman Pinscher,; 2 Newfoundland, 2 great dane		computer database only		[66]
			64	Irish Wolfhound	25 Irish Wolfhounds		[143]
			38	Newfoundland	36 Newfoundlands		[69]
SGCD	Y	N	25	Doberman Pinscher	10 Doberman Pinschers	[39, 142]	[35]
			64	Irish Wolfhound	25 Irish Wolfhounds		[143]
			38	Newfoundland	36 Newfoundlands		[69]
			25	Doberman Pinscher	13 Doberman Pinschers		[145]
STRN	N	Y	33	Boxer	16 Boxers	na	[62]
TAZ	Y	N	64	Irish Wolfhound	25 Irish Wolfhounds	[39]	[143]
TCAP	Y	N	8	Irish Wolfhound	5 Irish Wolfhounds	[39, 142]	[146]
			38	Newfoundland	36 Newfoundlands		[69]
			5	Doberman Pinscher	5 unspecified dogs without overt heart disease		[144]
TMOD	N	N	64	Irish Wolfhound	25 Irish Wolfhounds	na	[143]
TNNC1	Y	N	5	Doberman Pinscher	2 Labradors	[39, 142]	[67]
TNNI3	Y	N	38	Newfoundland	36 Newfoundlands	[39, 142]	[69]
TNNT2	Y	N	5	Doberman Pinscher	2 Labradors	[39, 142]	[67]
			5	Doberman Pinscher	5 dogs without overt heart disease		[144]
			38	Newfoundland	36 Newfoundlands		[69]
TPM1	Y	N	38	Newfoundland	36 Newfoundlands	[39]	[69]
			5	Doberman Pinscher	5 dogs without overt heart disease		[144]
TTN	Y	N	38	Newfoundland	36 Newfoundlands	[39, 142]	[69]
			2	Doberman Pinscher	5 mixed breeds		[147]
VCL	Y	N	5	Doberman Pinscher	5 dogs without overt heart disease	[39, 142]	[144]
			38	Newfoundland	36 Newfoundlands		[69]

Y = yes, N = no.