International Journal of Genomics / 2015 / Article / Fig 6

Research Article

Human Genes Encoding Transcription Factors and Chromatin-Modifying Proteins Have Low Levels of Promoter Polymorphism: A Study of 1000 Genomes Project Data

Figure 6

Comparison of Residual Variation Intolerance Score (RVIS) [21] percentiles for six groups of human genes with percentiles for the whole-genome dataset. (a) Cumulative percentage plots for the RVIS percentiles for six groups of human genes and for the whole-genome dataset. (b) Significance of the -test (-axis) where RVIS percentiles in six groups were compared with those for the whole-genome dataset as a function of the RVIS percentile threshold (-axis). The -test was applied as described in Section 2.