International Journal of Genomics / 2015 / Article / Tab 2

Review Article

Pharmacogenomics and Opioid Analgesics: Clinical Implications

Table 2

Case reports providing evidence on the impact of polymorphisms of metabolizing enzymes on the safety of hydrocodone or oxycodone.

AuthorMetabolizing enzymePolymorphism Adverse event

Madadi et al., 2010 [32]CYP2D6CYP2D641Death

Samer et al., 2010 [28]CYP2D632 alleles using the AmpliChip TMCYP450 DNA microarrayVolunteers who were CYP2D6 ultrarapid metabolizers experienced higher toxicity especially after CYP3A blockade with ketoconazole

Lemberg et al., 2010 [29]CYP2D6, CYP3A4, CYP3A5No effect of genotype in patients treated for malignant and nonmalignant chronic pain

Andreassen et al., 2012 [30]CYP2D6CYP2D62 × 2Genotype did not affect safety profile that is the incidence of nausea, tiredness, or cognitive failure in a cohort of cancer patients

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