First Genomic Analysis of Dendritic Cells from Lung and Draining Lymph Nodes in Murine Asthma

Table 2

Gene ontology analysis of 1607 regulated transcripts in CD8⁻ lung DCs.

Cellular component	GO ID	Total number of genes in category	Number of genes found	% genes found	Bonferroni corrected term-enrichment; value
Cytoplasm	5737	2435	201	8.3	1.7E − 07
External side of plasma membrane	9897	145	29	20.0	2.4E − 07
Cell surface	9986	202	34	16.8	1.1E − 06
Plasma membrane	5886	1127	104	9.2	4.9E − 05
Plasma membrane part	44459	783	77	9.8	2.0E − 04
Cytoplasmic part	44444	1706	141	8.3	2.7E − 04
Lytic vacuole	323	57	11	19.3	2.8E − 02
Lysosome	5764	57	11	19.3	2.8E − 02
Basolateral plasma membrane	16323	79	13	16.5	4.4E − 02

Transcripts that are found to be differentially regulated in CD8⁻ lung DCs from asthmatic-like versus healthy control mice were analyzed for statistical overrepresentation in “cellular component” GO annotations using a one-sided hypergeometric test and Bonferroni value correction. Only GO terms with a value <0.05 were considered to be overrepresented.