First Genomic Analysis of Dendritic Cells from Lung and Draining Lymph Nodes in Murine Asthma
Table 3
Gene ontology analysis of transcripts regulated in total DCs from lung-draining lymph nodes.
Cellular component
GO ID
Total number of genes in category
Number of genes found
% genes found
Bonferroni corrected term-enrichment value
Intracellular
5622
5869
239
4.1
5.0E − 11
Intracellular part
44424
5799
236
4.1
1.0E − 10
Intracellular organelle
43229
4906
205
4.2
2.2E − 09
Intracellular membrane-bounded organelle
43231
4389
174
4.0
2.4E − 05
Intracellular organelle part
44446
2247
103
4.6
4.3E − 05
Cytoplasm
5737
4078
162
4.0
8.2E − 05
Nucleus
5634
2346
104
4.4
1.8E − 04
Cytoplasmic part
44444
3065
127
4.1
3.2E − 04
Intracellular non-membrane-bounded organelle
43232
1127
58
5.1
8.6E − 04
Z disc
30018
54
8
14.8
1.2E − 02
I band
31674
61
8
13.1
2.8E − 02
Cell cortex
5938
99
10
10.1
4.6E − 02
Transcripts that are found to be differentially regulated in total lymph node DCs from asthmatic-like versus healthy control mice were analyzed for statistical overrepresentation in “cellular component” GO annotations using a one-sided hypergeometric test and Bonferroni value correction. Only GO terms with a value <0.05 were considered to be overrepresented.
