Research Article

A Quantitative Genomic Approach for Analysis of Fitness and Stress Related Traits in a Drosophila melanogaster Model Population

Table 5

Genes within associated GOs that explain >20% of the genetic variation within GO.

Trait/gene IDGene nameSelected evidence from FlyBase [32]

Metabolic rate
Gr28b Gustatory receptor 28bFeeding behavior, immune response, and thermosensory behavior
fz FrizzledWnt pathway, G-protein receptor activity, and Notch signaling
bru BrunelleschiMeiosis cytokinesis
dl Regulation of glucose metabolic processes, regulation of gene expression, and immune response
Fife Regulation of neurotransmitter secretion

Heat resistance
CG8745 Arginine catabolic processes to glutamate
CG8888 Metabolic processes
Syt1 Synaptotagmin 1Calcium ion binding and neurotransmitter secretion
Snap25 Synaptosomal-associated protein 25 kDaSNAP receptor activity and SNARE complex

Hsp70 expression
fz FrizzledWnt pathway, G-protein receptor activity, and Notch signaling
CG2807 Precatalytic spliceosome
Irc Immune-regulated catalaseResponse to oxidative stress
CG16941 Mitotic nuclear cell division
Pxd PeroxidaseResponse to ethanol
app ApproximatedZinc ion binding
bin3 Bicoid-interacting protein 3Regulation of translation
SoYb Sister of YbYb body

Viability benign
Baldspot Fatty-acid biosynthesis
GstS1 Glutathione S transferase S1Glutathione metabolic process
Sply Sphingosine-1-phosphate lyaseSphingolipid metabolism

Viability stress
Mkp3 Mitogen-activated protein kinase phosphatase 3Regulation of MAPK
Timeout DNA damage checkpoint
14-3-3εDetermination of adult lifespan and regulation of growth