Drug Target Identification and Prioritization for Treatment of Ovine Foot Rot: An In Silico Approach

Table 2

List of 29 proteins that are part of unique bacterial pathways that are completely absent in host and are also choke-point proteins.

S. number	PID	Unique metabolic pathway and associated choke-point protein(s)	EC number
(I)	Microbial metabolism in diverse environments
	146328927	Diaminopimelate epimerase	5.1.1.7
	146329519	Aspartate kinase	2.7.2.4
	146329782	2,3,4,5-Tetrahydropyridine-2-carboxylate N-succinyltransferase	2.3.1.117
	146329390	4-Hydroxy-tetrahydrodipicolinate reductase	1.17.1.8
	146329218	Aspartate-semialdehyde dehydrogenase	1.2.1.11
(II)	Lipopolysaccharide biosynthesis
	146329080	UDP-2,3-diacylglucosamine hydrolase	3.6.1.54
	146329113	Heptosyltransferase I	2.4.—.—
	146328792	Heptosyltransferase II	2.4.—.—
	146328867	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	3.5.1.108
	146329045	3-Deoxy-D-manno-octulosonic-acid transferase	2.4.99.12
	146329875	Lipid A biosynthesis lauroyl acyltransferase	2.3.1.—
	146329714	2-Dehydro-3-deoxyphosphooctonate aldolase	2.5.1.55
	146329082	3-Deoxy-manno-octulosonate cytidylyltransferase	2.7.7.38
	146329066	Tetraacyldisaccharide 4′-kinase	2.7.1.130
	146328829	Lipid-A-disaccharide synthase	2.4.1.182
	146329695	UDP-N-acetylglucosamine acyltransferase	2.3.1.129
(III)	Methane metabolism
	146328905	Phosphate acetyltransferase	2.3.1.8
	146329331	Acetate kinase	2.7.2.1
(IV)	Peptidoglycan biosynthesis
	146328739	Penicillin-binding protein 1B	2.4.1.129
	146329826	Penicillin-binding protein 2	—.—.—.—
	146328649	Cell division protein FtsI	2.4.1.129
	146328685	UDP-muramoylpentapeptide-N-acetylglucosaminyltransferase	2.4.1.227
	146329801	UDP-N-acetylmuramoyl-tripeptide–D-alanyl-D-alanine ligase	6.3.2.10
	146329007	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–2,6-diaminopimelate ligase	6.3.2.13
	146328783	UDP-N-acetylmuramoylalanine–D-glutamate ligase	6.3.2.9
	146329426	UDP-N-acetylmuramate-alanine ligase	6.3.2.8
	146329258	Phospho-N-acetylmuramoyl-pentapeptide-transferase	2.7.8.13
	146329145	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	2.5.1.7
	146328696	UDP-N-acetylmuramate dehydrogenase	1.3.1.98