Clinical Application of a Modular Genomics Technique in Systemic Lupus Erythematosus: Progress towards Precision Medicine

Table 2

Functional enrichment analysis from ToppGene. Hit count in query list is the number of genes from the list of significantly differentially expressed genes in that ontology. Hit count in genome is the number of described genes in the ontology.

ID	Name	value	-value Bonferroni	Hit count in query list	Hit count in genome
GO:0006955	Immune response			114	1416
GO:0019058	Viral life cycle			50	314
GO:0045087	Innate immune response			84	883
GO:0044764	Multiorganism cellular process			75	725
GO:0071357	Cellular response to type I interferon			27	76
GO:0060337	Type I interferon signaling pathway			27	76
GO:0051607	Defense response to virus			41	212
GO:0034340	Response to type I interferon			27	77
GO:0016032	Viral process			73	714
GO:0009615	Response to virus			47	310
GO:0002252	Immune effector process			67	628
GO:0006952	Defense response			107	1515
GO:0098542	Defense response to other organisms			50	401
GO:0043207	Response to external biotic stimulus			68	726
GO:0051707	Response to other organisms			68	726
GO:0009607	Response to biotic stimulus			68	760
GO:0048525	Negative regulation of viral process			22	78
GO:0034097	Response to cytokine			59	629
GO:0071345	Cellular response to cytokine stimulus			53	527
GO:0006414	Translational elongation			26	130
GO:0045069	Regulation of viral genome replication			18	58
GO:0006413	Translational initiation			29	179
GO:0019221	Cytokine-mediated signaling pathway			43	402
GO:0019079	Viral genome replication			19	76
GO:0043900	Regulation of multiorganism process			37	325
GO:0035455	Response to interferon-alpha			11	19