An Integrating Approach for Genome-Wide Screening of MicroRNA Polymorphisms Mediated Drug Response Alterations

Table 2

Experimental validated miRNA polymorphisms and their predictions in Mir2Drug databases.

SNP id

Gene ID

Gene symbol

miRNA

Allele

Wild free Energy

Mutation free energy

(kcal/mol)

Effect class

miRNASNP

PolymiRTS

MicroSNiPer

MirSNP

rs5186

185

AGTR1

hsa-miR-155-5p

A > C

−8.86

None

−8.86

Complete loss

Yes

Yes

Yes

Yes

rs4245739

4194

MDM4

hsa-miR-191-5p

C > A

−6.07

−0.098

−5.972

Partial loss

Yes

No

Yes

Yes

rs1434536

658

BMPR1B

hsa-miR-125b-5p

C > T

−7.27

−5.08

−2.19

Partial loss

No

No

Yes

Yes

rs3739008

4862

NPAS2

hsa-miR-17-5p

C > T

−9.56

−6.76

−2.8

Partial loss

Yes

Yes

No

Yes

rs3739008

4862

NPAS2

hsa-miR-519e-3p

C > T

−11.71

−8.91

−2.8

Partial loss

Yes

Yes

Yes

Yes

rs3739008

4862

NPAS2

hsa-miR-20b-5p

C > T

−7.49

−4.69

−2.8

Partial loss

Yes

Yes

No

Yes

rs1805672

10219

KLRG1

hsa-miR-584-5p

A > G

−6.9

None

−6.9

Complete loss

No

Yes

Yes

No

rs56109847

285242

HTR3E

hsa-miR-510-5p

G > A

−14.07

−9.69

−4.38

Partial loss

Yes

Yes

Yes

Yes

rs3203358

2626

GATA4

hsa-miR-583

C > G

−10.49

−5.98

−4.51

Partial loss

Yes

No

Yes

No

rs2278414

59348

ZNF350

hsa-miR-21-3p

C > T

None

−10.9

10.9

Complete gain

No

No

Yes

Yes

rs2278414

59348

ZNF350

hsa-miR-150-5p

C > T

−6.22

−10.96

4.74

Partial gain

Yes

Yes

Yes

Yes

rs868

7046

TGFBR1

hsa-let-7b-5p

A > G

−1.93

−0.24

−1.69

Partial loss

No

No

No

No