Blood Transcriptional Signatures for Disease Progression in a Rat Model of Osteoarthritis

Figure 1

Gene expression patterns in blood associated with OA progression in the rat model of the knee joint arthritis. Hierarchical clustering of MIA-induced transcriptional alterations in whole blood. Microarray results are shown as a heat map and include 41 transcripts with significantly different levels of transcript abundance. Colored rectangles represent transcript abundance 2, 14, 21, and 28 days after the intra-articular injection of the MIA of the gene labeled on the right. The intensity of the color is proportional to the standardized values (between −3 and 3) from each microarray, as indicated on the bar below the heat map image. Hierarchical clustering was performed with the dChip software using Euclidean distance and average linkage method. Major MIA-induced gene transcription patterns are arbitrarily described as A–C. The regulated genes from gene clusters A–C were labeled on the right.