Research Article

HuoXueJieDu Formula Alleviates Diabetic Retinopathy in Rats by Inhibiting SOCS3-STAT3 and TIMP1-A2M Pathways

Table 1

Top 10 canonical pathways identified using IPA (downregulated by HXJD).

Ingenuity canonical pathways valueAffected molecules

Role of macrophages, fibroblasts, and endothelial cells in rheumatoid arthritis1.15E−04TLR2, IL1R2, SOCS3, WNT10A, STAT3, IL17RA, and IRAK2
Inhibition of matrix metalloproteases4.07E−04MMP7, TIMP1, and A2M
IL-6 signalling9.12E−04IL1R2, SOCS3, STAT3, and A2M
IL-10 signalling2.04E−03IL1R2, SOCS3, and STAT3
Growth hormone signalling2.14E−03SOCS3, STAT3, and A2M
IL-22 signalling3.55E−03SOCS3, STAT3
Role of JAK family kinases in IL-6-type cytokine signalling3.89E−03SOCS3, STAT3
IL-9 signalling6.31E−03SOCS3, STAT3
Role of JAK2 in hormone-like cytokine signalling7.41E−03SOCS3, STAT3
Tetrahydrobiopterin biosynthesis I1.10E−02GCH1