Serum and Brain Metabolomic Variations Reveal Perturbation of Sleep Deprivation on Rats and Ameliorate Effect of Total Ginsenoside Treatment

Table 3

Differential expressed serum metabolites.

Class	Serum metabolites	M/WP		GS/M		GS/WP
		value	log2	value	log2	value	log2
Type 1	Stearic acid	2.90E−02	0.33	1.48E−02	−0.35	8.52E−01	−0.02
	2-Ethylhydracrylic acid	2.09E−04	1.01	2.71E−02	−0.47	6.21E−04	0.54
	2-Ketobutyric acid	1.18E−04	1.90	4.82E−02	−0.61	6.77E−04	1.29
	2-Hydroxybutyric acid	1.68E−03	2.78	2.05E−02	−1.35	4.90E−03	1.43
	3-Hydroxybutyric acid	1.64E−04	1.22	1.25E−02	−0.48	3.63E−03	0.74
	2-Aminobutyric acid	8.61E−04	1.13	2.37E−02	−0.63	8.20E−03	0.50
	Thymine	9.82E−05	0.97	7.52E−03	−0.57	2.12E−02	0.40
	α-Ketoisovaleric acid	2.81E−02	0.52	4.60E−01	−0.22	2.69E−01	0.30
	Glutaric acid	8.24E−03	1.21	7.56E−02	−0.73	1.48E−01	0.49
	Leucine	4.94E−02	0.32	1.91E−01	−0.19	2.69E−01	0.13
	Valine	1.25E−02	0.43	8.77E−02	−0.27	1.13E−01	0.16
	Glycerol	1.03E−02	0.38	6.30E−02	−0.35	7.85E−01	0.04
Type 2	Alanine	4.63E−06	−0.65	1.76E−02	0.24	3.49E−06	−0.41
	Proline	6.29E−04	−0.72	2.03E−02	0.37	7.55E−03	−0.35
	4-Hydroxyproline	8.49E−06	−1.13	7.56E−03	0.43	7.45E−05	−0.70
	Serine	6.23E−04	−0.70	4.98E−02	0.26	3.45E−03	−0.44
	Cysteine	5.74E−04	−0.55	6.84E−03	0.46	5.21E−01	−0.09
	Glycine	3.78E−04	−0.50	1.08E−03	0.35	8.99E−02	−0.15
	Erythronic acid	1.19E−02	−0.27	1.27E−02	0.23	5.95E−01	−0.04
	3-Indolepropionate	3.00E−02	−0.60	6.26E−02	0.41	3.86E−01	−0.19
	2-Ketoglutarate	4.85E−02	−0.60	2.68E−01	0.17	1.14E−01	−0.43
	Indoxyl sulfate	2.30E−02	−0.46	3.55E−01	0.23	3.17E−01	−0.23
Type 3	Sedoheptulose	6.15E−03	−1.16	5.32E−01	0.13	5.68E−03	−1.03
	Fructose	2.52E−03	−0.88	9.45E−01	−0.01	1.28E−03	−0.89
	D-Gluconic acid	6.01E−03	−1.58	2.28E−01	0.20	5.38E−03	−1.39
	Glycerol 3-phosphate	1.68E−02	−1.21	1.09E−01	0.27	2.70E−02	−0.94
	Threonine	5.77E−07	−0.56	5.36E−01	0.05	2.87E−06	−0.51
	Methionine	9.37E−04	−0.36	1.40E−01	0.16	2.94E−03	−0.20
	Glutamic acid	3.41E−03	−0.94	2.61E−01	0.16	4.66E−03	−0.78
	Aspartic acid	7.49E−04	−1.12	2.41E−01	0.23	1.08E−03	−0.89
	Asparagine	3.30E−03	−0.80	1.91E−01	0.31	3.84E−03	−0.49
	Orotic acid	2.82E−03	−0.54	5.83E−01	0.08	4.15E−03	−0.46
	Ethanolamine	2.01E−03	−0.45	8.71E−01	0.02	1.07E−03	−0.43
	3,4-Dihydroxybutyrate	2.48E−02	−0.32	5.57E−01	0.04	4.65E−02	−0.27
Type 4	Serotonin	2.33E−02	0.46	6.16E−01	0.09	3.47E−03	0.55
	Cholesterol	9.41E−03	0.65	7.50E−01	−0.05	5.30E−04	0.60
	Inositol phosphate	7.17E−04	0.67	4.63E−01	−0.10	1.59E−05	0.57