Biological Function of MicroRNA193a-3p in Health and Disease

Figure 3

Proposed model for the role of miR-193a-3p in the regulation of the chemoresistance in different cancer cell lines. (a) Involvement of high miR-193a-3p expression level in chemoresistance in HCC cells, BCa cells, and esophageal cancer cells. (b) Low levels of miR-193a-3p are involved in resistance to oxaliplatin in colon cancer cells. Altered expression of miR-193a-3p will adversely affect immediate targets indicated inside black boxes. In turn, these targets will affect several downstream pathways with green arrows and red lines representing functional activation and repression, respectively.