Biological Function of MicroRNA193a-3p in Health and Disease

Table 1

Regulation of miR-193a-3p expression by different mechanisms.

Mechanisms of regulation	Effect on miR-193a-3p expression	Sample type	Experimental procedures	Ref.
Transcription factors:
Max and RXRα	Downregulation	Transformed breast epithelial cells	ChIP; siRNA-mediated inhibition experiments	[3]
AML1/ETO	Downregulation	AML cell lines primary AML samples with t(8;12)	Luciferase reporter assay; ChIP	[4]
HNF4α	Upregulation	Liver from mice with liver-specific knockout of HNF4α	miRNA microarray and qPCR in Hnf4α-LivKO mice	[5]
DNA methylation:
DNA hypermethylation	Downregulation	AML cell lines; AML primary samples	MSP; Bisulfite sequencing	[9]
DNA hypermethylation	Downregulation	OSC carcinoma cells and primary AML samples	COBRA; Bisulfite sequencing	[8]
DNA hypermethylation	Downregulation	NSCL cancer cells; NSCL specimens	MSP; Bisulfite sequencing	[10, 11]
DNA hypermethylation	Downregulation	Highly metastatic osteosarcoma cells	Bisulfite sequencing	[12]
DNA hypomethylation	No effect	HCC cell lines; HCC specimens	MSP	[14]
DNA hypomethylation	No effect	Mesothelioma	MSP	[13]
Regulatory protein:
XB130	Downregulation	Thyroid carcinoma cells	shNA-mediated inhibition and ectopic expression experiments	[7]
Competing endogenous RNA (ceRNA) network:
Linc00152	Downregulation	Colon cancer cells	RIP; luciferase reporter assay	[17]
LncRNA-UCA1	Downregulation	NSCL cells	RIP; luciferase reporter assay	[18]