Review Article

Biological Function of MicroRNA193a-3p in Health and Disease

Table 2

miR-193a-3p gene targets validated experimentally.

Target genesFunctionsCell lineReferences

K-RasOncogene involved in many functions: antiapoptotic activity, angiogenesis, motility, cell growthBreast cancer
Lung cancer
[3, 29]
PLAUPromotes cancer invasion and metastasis; the interaction of uPA with its receptor induced also cell proliferation, migration, and expression of specific genesTransformed breast epithelial cells
Breast cancer
HCC
BCa
[3, 32, 33, 40]
Mcl-1Antiapoptotic gene, member of the Bcl-2 familyHeLa cells
Ovarian cancer
[30, 31]
ERBB4Induces a variety of cellular responses including mitogenesis and differentiation; triggers proliferation, invasion, and migrationLung cancer
NSCLC
[27, 37]
S6 K2Promote cell survivalNSCLC[37]
PepT1Transporter involved in the low uptake of small bacterial peptides in a normal colon and of dietary proteinsEpithelial colorectal adenocarcinoma[46]
c-kitOncogene. Activates many pathways involved in proliferation, differentiation, migration, and survivalAML[9]
Aml1/EtoChimeric protein associated with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiationAML[4]
HDAC3Regulates transcription and modulates cell growth an apoptosisAML[4]
DNMT3aDe novo DNA methylationAML[4]
Cyclin D1Cell cycle progressionAML
Breast cancer
[4]
[28]
E2F6Transcription factor with a main role in the control of the cell cycleOSCC[8]
Rab27BIncreased invasion and metastasis in cancerOsteosarcoma[12]
HMGB1Tissue repair and regeneration, migration, angiogenesis, endothelial recruitment, and proliferationEndothelial colony forming cell, ECFC[21]
HYOU-1Cytoprotective role in hypoxia-induced cellular perturbationEndothelial colony-forming cell, ECFC[21]
PSEN1Promote cell proliferationEsophageal squamous cell carcinoma
Bladder cancer
[45]
E2F1Transcription factor; control of the cell cycle and apoptosisHCC[15]
SRSF2Regulates constitutive and alternative splicing; induces proapoptotic splice forms of apoptotic genesHCC[15]
HIC2Putative transcriptional factorBCa[40]
HOXC9Transcription factor; role in morphogenesisBCa[43]
ING5Inhibit cell growth and induce apoptosisBCa[42]
LOXL4Biogenesis of connective tissue: catalyzes the first step in the formation of crosslinks in collagens and elastinBCa[41]
SLC7A5Large neutral amino acid transporter small subunit 1Thyroid carcinoma[7]
JNK1MAP kinases involved in proliferation, differentiation, transcription regulation, and developmentBreast cancer[26]