MicroRNAs as Biomarkers in Thyroid Carcinoma

Table 2

Studies of miRNAs in FNAB samples.

Samples	Histological diagnosis	miRNA expression (↑/↓)	Reference
8 (malignant)	PTC	↑ 181b, 221, 222	[43]
62 (8 malignant, 5 benign, 49 n.d.)	7 PTC, 1 Hürtle	↑ 146b, 155, 187, 197, 221; 222, 224	[27]
115 (37 malignant, 78 benign)	10 FTC or Hürtle (27 n.d.)	↑ 138	[65]
27 (20 malignant, 7 benign)	PTC	↑ 221	[66]
128 (88 malignant, 40 benign)	3 ATC, 13 FTC, 72 PTC	↑ 146b, 187, 221	[67]
		↓ 30d
141 (58 malignant, 83 benign)	58 PTC	↑ 146b, 155, 221	[68]
118 (70 malignant, 48 benign)	70 PTC	↑ 146b, 222	[69]
120 (45 malignant, 75 benign)	1 FTC, 2 ATC, 4 MTC, 8 Hürtle, 30 PTC	↑ 221, 222	[70]
44 (24 malignant, 20 benign)	24 FTC	↓ 148b-3p, 484	[64]

() related to malign samples; () ↑/↓: upregulated/downregulated. ATC: anaplastic thyroid carcinoma; FNAB: fine-needle aspiration biopsy; FTC: follicular thyroid carcinoma; MTC: medullary thyroid carcinoma; PTC: papillary thyroid carcinoma.