Research Article

Transcriptome-Based Modeling Reveals that Oxidative Stress Induces Modulation of the AtfA-Dependent Signaling Networks in Aspergillus nidulans

Table 2


Gene IDGene nameKnown/putative functionStress conditions
Control strainΔatfA mutant
MSBtBOOHDiamideMSBtBOOHDiamide

“Antioxidant enzyme” genes
AN9339catBCatalase1.4 ± 0.92.4 ± 1.21.2 ± 0.82.9 ± 1.03.1 ± 1.21.6 ± 0.8
AN10220ccp1Cytochrome c peroxidase5.3 ± 1.13.0 ± 1.25.1 ± 1.41.8 ± 0.74.7 ± 1.11.7 ± 0.9
AN0932glrAGlutathione reductase4.8 ± 1.41.3 ± 0.83.4 ± 0.81.7 ± 1.11.6 ± 1.11.2 ± 0.7
AN2846gpxAGlutathione peroxidase2.5 ± 1.34.2 ± 2.03.5 ± 1.11.8 ± 1.01.8 ± 0.92.8 ± 1.0
AN7567Glutaredoxin1.3 ± 0.92.5 ± 1.53.5 ± 0.71.1 ± 0.71.6 ± 1.11.9 ± 0.9
AN5831Glutathione transferase5.3 ± 1.43.1 ± 2.02.3 ± 1.63.3 ± 1.52.0 ± 1.01.6 ± 0.9
AN3581trxRThioredoxin reductase4.5 ± 1.02.9 ± 1.42.8 ± 1.44.1 ± 1.23.1 ± 1.04.9 ± 1.2
AN8692prxAThioredoxin-dependent peroxidase3.4 ± 1.03.8 ± 0.83.9 ± 1.43.8 ± 1.42.7 ± 0.83.9 ± 0.9
“Siderophore biosynthesis” genes
AN5823sidAL-Ornithine N5-monooxygenase2.4 ± 0.91.2 ± 0.6−2.5 ± 1.10.6 ± 0.81.2 ± 0.7−0.2 ± 0.5
AN8251hapXbZIP transcription factor2.1 ± 0.81.2 ± 0.70.8 ± 0.50.6 ± 0.61.5 ± 0.60.8 ± 0.5
“Iron-sulfur cluster assembly” genes
AN10584Cysteine desulfurase2.5 ± 0.81.6 ± 0.92.2 ± 1.00.4 ± 0.50.8 ± 0.50.2 ± 0.6
AN2508Cysteine desulfurase2.0 ± 0.81.3 ± 0.70.1 ± 0.50.0 ± 0.60.2 ± 0.50.4 ± 1.0
AN4655Iron-sulfur transferase1.9 ± 0.82.2 ± 1.02.1 ± 0.92.3 ± 0.93.0 ± 0.72.2 ± 1.1
AN0447Role in iron-sulfur cluster assembly3.2 ± 0.80.8 ± 0.63.1 ± 1.10.6 ± 0.70.9 ± 0.81.6 ± 0.7
AN1407Role in iron-sulfur cluster assembly2.2 ± 0.71.2 ± 0.92.9 ± 1.10.6 ± 0.80.6 ± 0.72.6 ± 0.7
AN2155Role in iron-sulfur cluster assembly3.1 ± 0.81.2 ± 0.63.3 ± 1.40.9 ± 0.71.4 ± 0.82.2 ± 0.7
AN3632Role in iron-sulfur cluster assembly2.9 ± 0.82.0 ± 0.90.5 ± 0.91.1 ± 0.62.7 ± 1.10.8 ± 0.6
AN5953Role in iron-sulfur cluster assembly1.8 ± 0.81.3 ± 0.71.6 ± 1.00.70 ± 1.11.3 ± 0.82.6 ± 0.8
AN8485Role in iron-sulfur cluster assembly2.5 ± 1.03.0 ± 1.21.4 ± 0.71.5 ± 0.51.3 ± 0.61.6 ± 0.5
AN10012Role in iron-sulfur cluster assembly3.1 ± 1.00.8 ± 0.61.2 ± 0.50.3 ± 0.50.4 ± 0.61.4 ± 0.9
AN11060Role in iron-sulfur cluster assembly3.1 ± 0.90.8 ± 0.71.2 ± 0.92.1 ± 1.10.9 ± 0.72.5 ± 0.9
“Two-component signal transduction system” genes
AN5296tcsAHistidine kinase2.7 ± 0.83.1 ± 1.01.9 ± 0.90.6 ± 0.61.9 ± 0.8−0.1 ± 0.5
AN1800tcsBHistidine kinase4.2 ± 1.12.2 ± 0.71.3 ± 0.72.4 ± 1.21.4 ± 0.8−0.3 ± 0.7
AN3101phkBHistidine kinase1.5 ± 0.8−0.5 ± 0.5−1.3 ± 0.4−0.5 ± 0.6−0.6 ± 0.6−1.7 ± 0.8
AN7945hk2Histidine kinase4.2 ± 1.1−0.4 ± 0.5−0.1 ± 0.70.2 ± 0.70.6 ± 0.70.4 ± 0.8
AN4113hk-8-2Histidine kinase2.6 ± 0.5−0.4 ± 0.60.4 ± 0.6−0.3 ± 0.7−1.2 ± 0.7−1.1 ± 0.6
AN6820hk-8-3Histidine kinase2.9 ± 1.0−0.9 ± 0.4−2.0 ± 1.10.3 ± 0.60.4 ± 0.60.9 ± 0.7
AN2363hk-8-6Histidine kinase3.5 ± 1.31.8 ± 0.8−0.3 ± 0.60.6 ± 0.60.2 ± 0.7−0.9 ± 0.5
“Nitrate utilization” genes
AN1006niaDNitrate reductase−1.0 ± 0.5−2.2 ± 1.1−4.3 ± 1.20.5 ± 0.6−2.2 ± 0.9−1.9 ± 1.1
AN1007niiANitrite reductase−1.5 ± 0.7−1.4 ± 0.7−3.2 ± 1.00.2 ± 0.6−1.9 ± 1.0−2.1 ± 1.2
AN1008crnANitrate transporter−4.8 ± 1.2−1.1 ± 0.7−2.1 ± 0.90.9 ± 0.8−2.4 ± 1.1−0.5 ± 0.5
Other genes
AN1168cch1Calcium ion transporter0.1 ± 0.60.8 ± 0.7−1.3 ± 0.6−0.6 ± 0.71.3 ± 0.8−0.4 ± 0.7
AN1628enaBCalcium ion transporter−1.5 ± 1.12.5 ± 1.2−1.2 ± 0.70.4 ± 0.61.2 ± 0.50.2 ± 0.7
AN4920pmcBCalcium ion transporter0.7 ± 0.81.9 ± 0.92.1 ± 1.1−1.3 ± 0.61.1 ± 0.51.4 ± 0.7
AN8842mid1Calcium ion transporter0.5 ± 0.70.8 ± 0.70.3 ± 0.6−1.3 ± 0.71.3 ± 0.6−0.2 ± 0.6

Relative transcription levels were quantified with the ΔΔCP value. Mean ± S.D. values are presented. The actA (AN6542) gene was used as reference gene. Significantly differ from zero according to Student’s t-test (, ).