An Exploration of Gene-Gene Interactions and Their Effects on Hypertension

Table 2

Genotype counts for SNP pairs and odds ratios relative to the double major allele homozygote genotype in the offspring sample.

(a)

		rs9489622
	rs4235144	GG	GA	AA
Controls	CC	0	0	0
	CT	0	18	14
	TT	278	550	292
Hypertension	CC	0	0	0
	CT	17	7	1
	TT	262	556	315
OR^a relative to TT/AA (95% CI)	CC	—	—	—
	CT	—	0.36 (0.148–0.876)	0.07 (0.009–0.507)
	TT	0.87 (0.693–1.102)	0.94 (0.769–1.142)	1

(b)

		rs3913226
	rs2058798	TT	TC	CC
Controls	AA	0	0	0
	AG	2	19	1
	GG	25	310	781
Hypertension	AA	0	0	0
	AG	0	5	27
	GG	30	332	745
OR^a relative to GG/CC (95% CI)	AA	—	—	—
	AG	0.21 (0.010–4.375)	0.28 (0.103–0.743)	28.30 (3.836–208.829)
	GG	1.26 (0.733–2.159)	1.12 (0.934–1.350)	1

(c)

		rs17284390
	rs1909884	GG	GA	AA
Controls	AA	2	24	132
	AG	8	117	398
	GG	15	108	351
Hypertension	AA	7	46	82
	AG	15	110	428
	GG	0	76	391
OR^a relative to GG/AA (95% CI)	AA	3.14 (0.648–15.225)	1.72 (1.029–2.877)	0.56 (0.409–0.761)
	AG	1.68 (0.705–4.018)	0.84 (0.627–1.137)	0.97 (0.792–1.177)
	GG	0.03 (0.002–0.486)	0.63 (0.456–0.876)	1

(d)

		rs12484954
	rs17688362	CC	CG	GG
Controls	TT	3	40	8
	TG	60	198	121
	GG	88	325	307
Hypertension	TT	12	9	26
	TG	57	160	149
	GG	109	363	257
OR^a relative to GG/GG (95% CI)	TT	4.78 (1.334–17.117)	0.27 (0.128–0.564)	3.88 (1.728–8.723)
	TG	1.13 (0.762–1.691)	0.97 (0.740–1.260)	1.47 (1.099–1.969)
	GG	1.48 (1.068–2.050)	1.33 (1.067–1.668)	1

Note. . ^aOR is odds ratio.