The Role of miRNAs as Biomarkers for Pregnancy Outcomes: A Comprehensive Review

Table 3

Studies reporting an association between alteration of miRNA expression and PTB.

Authors and year	Study design	Enrolled population	Samples	Gestational age at sampling (weeks)	Techniques	↑ miRNAs	↓ miRNAs
Elovitz et al., 2014 [14]	Retrospective	10 cases + 10 controls	Cervical cells	<37	Affymetrix GeneChip miRNA array + qRT-PCR	miR-143, miR-145 (cases)	—
Elovitz et al., 2015 [6]	Retrospective	40 cases + 40 controls	Maternal serum	<30	miRNA array	miR-4695-5P, miR-665 (stem-loop), and miR-887 (stem-loop) (cases)	miR-200a (cases)
Sanders et al., 2016 [15]	Prospective	60 pregnant women, 4 lost at follow-up	Cervical cells	<37	NanoString	miR-21, miR-30e, miR-142, miR-148b, miR-29b, and miR-223 (cases)

qRT-PCR: quantitative real-time polymerase chain reaction.