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International Journal of Genomics
Volume 2017, Article ID 8737649, 10 pages
https://doi.org/10.1155/2017/8737649
Research Article

Overexpression of Chromosome 21 miRNAs May Affect Mitochondrial Function in the Hearts of Down Syndrome Fetuses

1Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy
2Institute of Experimental Endocrinology and Oncology, National Research Council, 80131 Naples, Italy
3Department of Biosciences and Nutrition, Karolinska Institutet, 17177 Stockholm, Sweden

Correspondence should be addressed to Anna Conti; ti.aninu@itnocna

Received 12 May 2017; Revised 20 July 2017; Accepted 2 August 2017; Published 5 September 2017

Academic Editor: Davide Barbagallo

Copyright © 2017 Antonella Izzo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Table 1. Targets of let-7c significantly downregulated in DS fetal hearts with a (FC)>|1,2| and p-value<0,05. Number of predictions by different databases are also indicated. Table 2. Targets of miR-155 significantly downregulated in DS fetal hearts with a (FC)>|1,2| and p-value<0,05. Number of predictions by different databases are also indicated. Table 3. Targets of miR-99a significantly downregulated in DS fetal hearts with a (FC)>|1,2| and p-value<0,05. Number of predictions by different databases are also indicated. Figure 1. SLC25A4/ANT1 expression in heart tissue by qRT-PCR. Real-time PCR of SLC25A4/ANT1 in trisomic hearts confirmed the downregulation obtained by microarray analysis. Results are expressed as relative mean values ± SEM of 3 trisomic samples (DSH), compared with control hearts (NH) set equal to 1. ∗∗ p <0.01. P-value expresses statistical significance for trisomic versus non trisomic sample comparisons.

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