Overexpression of Chromosome 21 miRNAs May Affect Mitochondrial Function in the Hearts of Down Syndrome Fetuses

Table 1

Targets of let-7c-5p significantly downregulated in DS hearts and belonging to gene ontology cellular component category “mitochondrion.” Twenty-six genes were observed instead of the expected 6.49 genes with .

Gene symbol	Description	FC
AKAP8	A-kinase anchoring protein 8	−1,361
COX10	COX10, heme A: farnesyltransferase cytochrome c oxidase assembly factor	−1,307
COX5A	Cytochrome c oxidase subunit 5A	−1,263
DLAT	Dihydrolipoamide S-acetyltransferase	−1,678
DLST	Dihydrolipoamide S-succinyltransferase	−1,724
FKBP4	FK506 binding protein 4	−1,558
GADD45GIP1	GADD45G interacting protein 1	−1,664
GHITM	Growth hormone inducible transmembrane protein	−1,477
HSPB7	Heat shock protein family B (small) member 7	−1,422
MECP2	Methyl-CpG binding protein 2	−1,22
MPC1	Mitochondrial pyruvate carrier 1	−1,339
MRPL33	Mitochondrial ribosomal protein L33	−1,333
MRS2	MRS2, magnesium transporter	−1,416
NDUFS3	NADH: ubiquinone oxidoreductase core subunit S3	−1,314
NMT1	N-myristoyltransferase 1	−1,443
NOL7	Nucleolar protein 7	−1,299
PANK2	Pantothenate kinase 2	−1,361
PCCB	Popionyl-CoA carboxylase beta subunit	−1,335
PDHA1	Pyruvate dehydrogenase (lipoamide) alpha 1	−1,524
PGS1	Phosphatidylglycerophosphate synthase 1	−1,233
SDHC	Succinate dehydrogenase complex subunit C	−1,23
SLC25A12	Solute carrier family 25 member 12	−1,408
SLC25A4	Solute carrier family 25 member 4	−1,55
TIMM23	Translocase of inner mitochondrial membrane 23	−1,508
UQCC1	Ubiquinol-cytochrome c reductase complex assembly factor 1	−1,517
UQCRFS1	Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	−1,292