Overexpression of Chromosome 21 miRNAs May Affect Mitochondrial Function in the Hearts of Down Syndrome Fetuses

Table 2

Targets of miR-155-5p significantly downregulated in DS hearts and belonging to gene ontology cellular component category “mitochondrion.” Eight genes were observed instead of the expected 2.34 genes with .

Gene Symbol	Description	FC
DLAT	Dihydrolipoamide S-acetyltransferase	−1,678
HSPB7	Heat shock protein family B (small) member 7	−1,422
LPIN1	Lipin 1	−1,838
MECP2	Methyl-CpG binding protein 2	−1,22
NDUFS3	NADH: ubiquinone oxidoreductase core subunit S3	−1,314
NT5C	5, 3-nucleotidase, cytosolic	−1,524
SIRT5	Sirtuin 5	−1,255
YWHAQ	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta	−1,364