Overexpression of Chromosome 21 miRNAs May Affect Mitochondrial Function in the Hearts of Down Syndrome Fetuses
Table 2
Targets of miR-155-5p significantly downregulated in DS hearts and belonging to gene ontology cellular component category “mitochondrion.” Eight genes were observed instead of the expected 2.34 genes with .
Gene Symbol
Description
FC
DLAT
Dihydrolipoamide S-acetyltransferase
−1,678
HSPB7
Heat shock protein family B (small) member 7
−1,422
LPIN1
Lipin 1
−1,838
MECP2
Methyl-CpG binding protein 2
−1,22
NDUFS3
NADH: ubiquinone oxidoreductase core subunit S3
−1,314
NT5C
5, 3-nucleotidase, cytosolic
−1,524
SIRT5
Sirtuin 5
−1,255
YWHAQ
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta