Research Article

Topological Characterization of Human and Mouse m5C Epitranscriptome Revealed by Bisulfite Sequencing

Figure 1

Distribution of transcriptome m5C modification sites in human and mouse. (a) The pie chart shows transcriptome-wide distribution of m5C sites in MCF10A, MDA-MB-468, mouse embryonic stem cell (ESC), and whole brain. The majority of the identified m5C sites are located on mRNAs. (b) Graph showing status of m5C frequency in different regions of mRNA. The result indicates that detected cytosine sites are consistently enriched at the 5UTR on mRNA compared with the CDS and 3UTR.