Topological Characterization of Human and Mouse m⁵C Epitranscriptome Revealed by Bisulfite Sequencing

Figure 1

Distribution of transcriptome m⁵C modification sites in human and mouse. (a) The pie chart shows transcriptome-wide distribution of m⁵C sites in MCF10A, MDA-MB-468, mouse embryonic stem cell (ESC), and whole brain. The majority of the identified m⁵C sites are located on mRNAs. (b) Graph showing status of m⁵C frequency in different regions of mRNA. The result indicates that detected cytosine sites are consistently enriched at the 5UTR on mRNA compared with the CDS and 3UTR.

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