Research Article

Topological Characterization of Human and Mouse m5C Epitranscriptome Revealed by Bisulfite Sequencing

Figure 7

Differential m5C mRNA methylation in different tissues. (a) Pie-diagram showing hypo- and hypermethylation in MDA468 when compared to MCF10A. A total of 47 differential methylated genes were identified between the breast cancer (MDA-MB-468) and normal control cell lines (MCF10A) with primary hypomethylation under cancer condition. (b) Bar graph showing odds ratio of hypermethylation sites with respect to all differentially methylated sites on different regions of mRNA. Hypermethylated sites were strongly enriched in 5UTRs. (c) Pie diagram showing hypermethylation in mouse embryo stem cells when compared to whole brain cells. (d) Bar graph showing odds ratio of hypermethylation sites with respect to all differentially methylated sites on different regions of mRNA in the mouse experiment. Hypermethylated sites were strongly enriched in 5UTRs.
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